Novel s-Triazinyl piperazines: Design, synthesis, characterization and anti-microbial activity

Eleven compounds have been synthesized in a series of [1, 3, 5] triazine analogues which, in addition to 4-amino benzonitrile, contain 8-hydroxy quinoline and different piperazines as well as piperidine substituents on the C-6 position of s-triazine ring. The title compounds were then evaluated for their in vitro microbial activity against 2 gram –Ve bacteria (E.coli, P. aeruginosa), 2 gram +Ve bacteria (S. aerues, B. subtilis) and 2 fungal species (C. albicans and A. niger). The most of the synthesized compounds have shown promising antimicrobial activity. All the final compounds were structurally elucidated on the basis of IR, H NMR, C NMR and elemental analysis.